7-fold increase in plasma CoQ10 in one month and still rising

120 mg daily supplementation

Highest plasma CoQ10 levels

Benefits of Q-GEL™ Softsules®

• Q-GEL™ provides 300%+ higher CoQ10 serum levels than conventional dosage forms (6 to 7 fold increase over baseline levels).
• Q-GEL™ at recommended dosages achieves therapeutic levels of CoQ10 in three weeks or less.
• Q-GEL™ costs substantially less than regular CoQ10 supplements, based on relative bioavailability.
• Most importantly, Q-GEL™ provides serum CoQ10 levels that are unattainable with con ven tion al sup ple ments.
• Lower dosages of Q-GEL™ are required for effective serum levels.
• Q-GEL™ absorption is independent of composition of diet and proximity to meals.
• Q-GEL™ is the only CoQ10 supplement that has undergone clinical scrutiny - including a relative bioavailability study. Additional studies and trials are ongoing. Results will be an nounced upon com ple tion of these trials.
• Q-GEL™ is the only Coenzyme Q10 supplement formulated via the patent pending Bio-Solv technology.
• Q-GEL™ is the preferred dosage form recommended by leading physicians and cardiologists. Stephen T. Sinatra, M.D., F.A.C.S. at the New England Heart Center, says "Your new Q-Gel has lit er al ly made the dif fer ence in the quality of life in many of my patients." Frederick J. Vagnini, M.D., F.A.C.S. of the Cardiovascular Wellness Center reports "I have found it to be one of the most energy enhancing supplements currently available.

Availability study. Additional studies and trials are ongoing.

Patent pending Bio-Solv technology.

A New Coenzyme Q10 Preparation With Enhanced Bioavailability.

R. Chopra, R. Goldman and H.N. Bhagavan.
Coenzyme Q10 is commercially available as a nutritional supplement in various dosage forms. None of the dosage forms tested to date are able to provide consistent and adequate plasma CoQ10 values. In addition, because of the extremely poor solubility of CoQ10 in aque ous systems, the currently available CoQ10 products exhibit a total lack of dissolution when tested by standard methodology. In order to enhance the relative bioavailability of CoQ10, a new formulation and process (BioSolv™, BioSytes) was used to prepare softgel capsules (Q-GEL™) which provide 100% dissolution when tested by the USP method. These softgel cap sules (Q-GEL™) were compared with a compressed tablet, a powder filled hardgel capsule and a commercially available softgel capsule in a relative bioavailability study. Twenty-four adult male subjects were divided into four groups, with the subjects in each group receiving 120 mg of CoQ10 daily (single dose) of one of four different formulations for three weeks. Plasma was collected at 0, 1, 2 and 3 weeks for CoQ10 determinations by HPLC. Relative bioavailability was calculated using the plasma CoQ10 AUC [Dr. Swarwtout's note: AUC stands for "Area Under the Curve", a method for measuring relative bioavailability] . The data show that compared with the stan dard softgel capsule, hardgel cap sule and tablet (all three having similar relative bioavailability), the Q-GEL softgel formulation is vastly superior (ca. 300%) (FASEB Journal, 11:A586, 1997).