DMSA
meso-2,3-dimercaptosuccinic acid

DMSA derives its name from “mercurius captans”, Latin for capturing mercury. The organic sulfur of DMSA's thiol (-SH) group binds heavy metals in soft tissues:

• blood
• brain
• kidney
• liver

“With respect to redistribution of mobilized Pb to critical organs and the magnitude of decline in soft tissue Pb concentration, DMSA appears to be a safe and particularly effective chelator and thus may be a viable alternative to CaNa2EDTA” (Cory-Slechta DA, Mobilization of lead over the course of DMSA chelation therapy and long-term efficacy. J Pharmacol Exp Ther 1988 Jul; 246(1):84-91).

Heavy-Metal: Cleansing (Phase 4)

DMSA is safe and effective for children in recommended doses. DMSA “is labeled for use in children with blood lead concentrations in excess of 45 micrograms/dL.” Data also shows that DMSA is effective for reducing the lead burden in children with blood levels of 25 to 45 micrograms/dL (Berlin, CM Jr, Lead poisoning in children. Curr Opin Pediatr 1997 Apr;9(2): 173-7).

DMSA capsules can be taken alone or with other chelating agents for the detoxification of heavy metals including:

• mercury (Hg)
• lead (Pb)
• cadmium (Cd)
• arsenic (As)

Oral chelation with DMSA is safe and effective even in adults with severe lead toxicity (Lifshitz M, et al, The effect of 2,3 dimercaptosuccinic acid in the treatment of lead poisoning in adults. Ann Med 1997 Feb; 29(1):83-5).

Dialkyltin compounds have been widely used in industry and agriculture, mainly as biocides, catalysts and plastic stabilizers. Toxic effects occur in the immune system, the bile duct, liver and pancreas. In a manner similar to organoarsenic, the toxicity of the dialkyltin compounds is related to reactions with biological dithiol groups. DMSA diminishes the production of bile duct, pancreas and liver lesions and inhibits the development of fibrosis of the pancreas and cirrhosis of liver in lab animals exposed to these toxic chemicals. The decrease in the biliary excretion of these compunds by DMSA seems to be the reason for the pronounced protective effects of DMSA on the bile duct, pancreas and liver. For these reasons DMSA has been recommeded for the treatment of poisonings with dibutyltin compounds (Merkord J, et al, Antidotal effects of 2,3-dimercaptopropane-1-sulfonic acid (DMPS) and meso-2,3-dimercaptosuccinic acid (DMSA) on the organotoxicity of dibutyltin dichloride (DBTC) in rats. Hum Exp Toxicol 2000 Feb; 19(2):132-7).

Precautions to minimize adverse effects of DMSA administration include:

• Consume 4 ounces per 1/2 hour of Sango-coral water or Alkaline Microwater throughout daylight hours of the cleanse.
• Take smaller doses if senstive generally
• Take smaller doses if kidneys show stress
• Watch and support liver function, considering Silymarin
• Take Chitosan X-tra fiber (3 to 15 a day at least 3 hours away from any beneficial oils if possible) to support bowel elimination route and prevent recycling of heavy metals and other toxins
• Do enemas, implants or colonic irrigation if necessary or helpful
• Make sure to take extra minerals: a multiple-mineral supplement (StarGold, 1 or 2 capsules twice a day, or Kreb Cycle Minerals , 1 twice a day) plus Magnesium Glycinate (1 capsule twice a day) away from DMSA
• Take two to four Ester-C Complex three times a day
• Biofield analysis remedies should be tested and adjusted at least monthly

• A 50 kg (110 lb) person may take up to 500 mg spread out through the day for up to five days (maximum: 10mg for each kilogram of the body-mass for each day)
• A 50 kg (110 lb) person may then take up to 1000 mg spread through the day for up to 2 weeks (maximum: 10mg/kg b.i.d.)
• Give your system a rest from the DMSA for 2 weeks while continuing other remedy support
• Repeat DMSA cleansing cycle as tolerated and indicated by clinical, diagnostic and/or energetic tests

Contraindications

Avoid any intense detoxification during pregnancy and lactation. Always give your system a rest after taking DMSA for up to 3 weeks.

What to watch for:

Whenever taking DMSA, watch for any changes in urinary tract gastrointestinal and skin symptoms:

• gastrointestinal symptoms
• nausea or vomiting
• loose stool or diarrhea
• loss of appetite
• metallic taste in the mouth
• allergies
• skin reactions
• kidney pain
• mid or low back pain