Morinda citrifolia (Noni)
Research:

Noni has a long history as a traditional medicine around the world and now extensive research to help us understand why this medicinal plant was so important to the Polynesians that they took it with them on their life and death journey to rediscover Eden in Hawai'i.

Xeronine and Cellular Regeneration

Research in Hawai'i by Dr. Ralph Heinicke identifies a pharmacologically active compound in Noni. Dr. Heinicke spends over 45 years studying the effects on all cells of Xeronine, a small and physiologically active alkaloid. Noni juice is found to contain the precursor of xeronine called pro-xeronine. Pro-xeronine is converted by an enzyme in Noni juice into xeronine in the intestines. Dr. Heinicke's theorizes that xeronine stimulates repair of cellular damage. Dr. Heinicke states that the main function of xeronine is the regulation of the strength and shape of certain proteins. Because proteins have so many different functions in the body as enzymes as well as structural components, this explains why Noni juice has such a wide range of physiological effects.

Anti-Cancer Activity of Morinda citrifolia on Intraperitoneally implanted Lewis Lung Carcinoma in Syngenic Mice

A. Hirazumi, E. Furrasawa, S.C. Chou & Y. Hokama. Proc West Pharmacol Soc. 37: 145-146 (1994).

Researcher Annie Hirazumi at the University of Hawaii became interested in noni when her father helped a good friend with the juice. Then Annie gave pure Noni juice to a her dying dog. When the dog had a miraculous recovery, Annie knew that this fruit was worthy of greater research efforts.

C57Bl/6 mice are susceptible to Lewis Lung Carcinoma (LLC) when injected with active cells . Without treatment, these mice die in 9 to 12 days. Mice given Noni juice for five days extended their life span by 105% to 123%. 9 out of 22 mice given noni even lived for over 50 days. Noni juice "seems to act indirectly by enhancing host immune system involving macrophages and/or lymphocytes."

Induction of Normal Phenotypes in RAS-transformed cells by Damnacanthal from Morinda citrifolia

T. Hiramatsu, M. Imoto, T. Koyano, K. Umezawa. Cancer Letters 73 (1993) 161-166.

Japanese researchers studied 500 tropical plant extracts on the K-ras-NRK cell, a precursor to some types of cancer. Damnacanthal, a compound in Noni, inhibits Ras function. Damnacanthal also inhibits Epstein-Barr virus (EBV) early-antigen activation. Damnacanthal from noni is the most effective at inhibiting Ras function among 500 herbal extracts in the test.

Analgesic and Behavioral Effects of Morinda citrifolia

C. Younos, A. Rolland, J. Fluerentin, M. Lanhers, R. Misslin, F. Mortier. Planta Medica 56 (1990). 430-434.

French scientist Chafique Younos tests analgesic and sedative effects of noni extracts. Traditional use of noni includes general analgesia. Noni extract is found non-toxic with significant, dose-related, central analgesic activity in mice. "These findings validate the traditional analgesic properties of this plant."

Phase 1 Noni effects:

• anti-tumor: retard tumor growth by stimulating immunity.
• anti-cancer: arresting the growth of implanted cancerous RAS cells.

Phase 2 Noni effects:

• alterative: increase cellular function.
• antiseptic: effective against at least seven pathogenic bacteria
• antiparisitic: effective against parasites.

Phase 3 Noni effects:

• regenerative: stimulation of cellular regeneration.
• anti-fungal: effective against fungus .

Phase 4 Noni effects:

• analgesic: general pain relieving effect.

Phase 5 Noni effects:

• adaptogen: good for every cell in the body

System 1 support:

• physical support for enhancing performance

System 2 support:

• immune system support for fighting diseases and infections

System 3 support:

• digestive system support for increasing nutrient absorption and cellular utilization

System 4 support:

• nervous system support for increase in mental clarity and attention span

System 5 support:

• hair support for a healthy shine
• skin support for a healthy glow.

Aloha!