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Atherosclerosiscopyright © 1996, G. M. Swartwout, A.B., B.D., D.N., O.D., F.I.C.A.N., F.C.S.O. Are Heart Attacks and Strokes A Sign of Chronic Nutritional Deficiency? In 1969, McCully presented the first findings on a relationship between elevated homocysteine levels and atherosclerosis based on autopsies of individuals with abnormally high homocysteine concentrations due to rare metabolic defects. Since then, more than 20 controlled, cross-sectional and prospective studies of over 2,000 subjects have added mounting evidence that even mildly elevated homocysteine levels, within the medically normal range, can double and triple cardiovascular disease including heart attack and stroke. A number of recent studies published between 1992 and 1995 show that increasing homocysteine levels are related to increasing levels of risk for both carotid artery disease, and heart disease. How does homocysteine contribute to cardiovascular disease? Animal studies show that increased levels of homocysteine can cause vascular lesions (a Phase 4 toxicity effect) in as little as three months. Still in Phase 4, homocysteine may be directly toxic to the delicate endothelial cells that line all healthy blood vessels, preventing these cells from relaxing and producing toxic oxides of nitrogen. As the condition degenerates into Phase 3, homocysteine may then cause proliferation of smooth muscle cells, which is an important part of plaque formation. In Phase 2, homocysteine can trigger thrombus formation via thrombomodulin and activation of protein C causing rapid deterioration in function, as with stroke and heart attack. This elevation of homocysteine can be prevented in most cases by simply taking in a good level of the B vitamins, especially folate, B6 and B12. The higher your intake of folate, the lower your homocysteine level. At least 400 mcg of folate is needed daily to maintain low homocysteine levels. Thus about 40% of the American population is not getting enough folate. Sadly, the RDA for folate has recently been reduced from 400 mcg to 200 mcg. In the Framingham Heart Study, 21% of the population had levels of homocysteine associated with a three-fold increase in cardiovascular risk. The table below shows the SAD (Standard American Diet) state of today�s diet for the three B vitamins shown to prevent homocysteine formation, and thus atherosclerosis.
The diagram below summarizes the key metabolic pathways in homocysteine metabolism, and shows how the B vitamins play a key role, when present in the diet, or dietary supplementation at adequate levels, in preventing increased levels of homocysteine that are associated with atherosclerosis. Homocysteine Metabolism
Folate, the most commonly deficient vitamin, is methylated to methyl-THFA. Remission Foundation recommends TMG (Trimethyl Glycine) to enhance the methylation processes of the body, including recycling homocysteine to SAMe, which elevates mood, reverses atherosclerosis and prevents cancer.[see print document for diagram and footnotes] Many other natural factors in atherosclerosis prevention and therapies have been studied and reported as potentially beneficial in the scientific literature, including:
Other critical factors to avoid for successful prevention and reversal include:14,15
The Heavy Metal Connection One approach to detoxifying heavy metals that can trigger atherosclerosis is chelation therapy. The term chelation comes from 'claw' and refers to the ability of certain compounds to grab heavy metals and remove them safely from the body. Chelation can be performed intravenously using the chelating agent EDTA, or when time permits a safer and slower administration, it can be done orally with supplements. Elation! is an excellent oral chelation program available through Remission Foundation. This program is a perfect health restoration and prevention program for reducing the risk of cardiovascular disease including heart attack and stroke, the #1 and #3 killers of our time. To improve fat and cholesterol metabolism, one component of the program contains soluble dietary fibers, lecithin, and other nutrients involved in the physiology of lipoproteins, cholesterol and bile acids, plus EDTA which is also used to preserve freshness. Another component of the program combines the nutritional benefits of allicin-rich garlic with alfalfa, parsley, citrus extract, chlorophyll, aloe and spearmint. Garlic is an excellent source of organic sulfur, important in the detoxification of heavy metals. Garlic also has powerful benefits for cardiovascular health. Additional EDTA is incorporated in this supplement as well. The program also includes Chlorella, which has been found to remove mercury better than any other supplement tested, plus a special non-flush form of niacin, and lysine to pull cholesterol off the artery walls and into solution so it can be removed. Another oral chelation agent available to pull out lead and mercury is DMSA. For more details on oral chelation, see the Chelation report. |
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